Beclomethasone dipropionate

Research use only, not for human use.

An anti-inflammatory, synthetic glucocorticoid. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of ASTHMA.

An anti-inflammatory, synthetic glucocorticoid. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of ASTHMA.(In Vitro):Beclometasone dipropionate (1-100 nM; 20 min) inhibits STAT-1 expression and reduces the levels of iNOS, ROS and NT generated by rhIL-17A in 16HBE cells.(In Vivo):Beclometasone dipropionate (150 μg/kg; nebulization; male BALB/c mice) relieves asthma and decreases total cell number and relative eosinophil number.

Beclometasone dipropionate (1-100 nM; 20 min) inhibits STAT-1 expression and reduces the levels of iNOS, ROS and NT generated by rhIL-17A in 16HBE cells. Western Blot Analysis Cell Line:16HBE cells Concentration:1, 10 and 100 nM Incubation Time:20 min Result:Reduced the levels of iNOS, ROS and NT generated by rhIL-17A.

Beclometasone dipropionate (150 μg/kg; nebulization; male BALB/c mice) relieves asthma and decreases total cell number and relative eosinophil number. Animal Model:Ten-week-old male Balb/c mice.Dosage:5 mg/kg (100 μg/ml for 60 min).Administration:Orally at 24 h and 1 h before the LPS aerosol.Result:Significantly (P < 0.05) inhibited the decrease of IL-10 level in BAL fluid induced by LPS exposure.Markedly reduced the release of both MMP-2 and MMP-9.Animal Model:Male BALB/c mice with asthma Dosage:150 μg/kg Administration:Nebulization Result:Decreased total cell number and relative eosinophil number in BALF.

Beclomethasone dipropionate | Clenil | Qvar | Beconase | alanase | Vancenase

Endocrinology/Hormones

GR

Glucocorticoid Receptor

Inflammation/Immunology

——

5534-09-8

521.04

C28H37ClO7

>98% (HPLC)

DMSO: 10 mM

CCC(O[C@]1(C(COC(CC)=O)=O)[C@@H](C)C[C@@]2([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]12C)=O)=O

(8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-[2-(propionyloxy)acetyl]-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate

(-20℃)

With Ice Pack

≥ 2 years